Reversing gum disease

Periodontal disease (gum disease) is a serious infection. If left unchecked, it can destroy the jawbone and lead to tooth loss. The disease is also associated with a higher risk of diabetes and cardiovascular disease.

The current treatment for periodontal disease involves opening the infected gum flaps and adding bone grafts to strengthen the teeth. But in new research published recently in the journal Frontiers in Immunology, Forsyth Institute, USA, scientists have discovered that a specific type of molecule may stimulate stem cells to regenerate, reversing the inflammation caused by periodontal disease. This finding could lead to the development of new therapeutics to treat a variety of systemic diseases that are characterised by inflammation in the body.

For the study, Drs Alpdogan Kantarci and Emmanuel Albuquerque and their team removed stem cells from previously extracted wisdom teeth and placed them onto petri dishes. The researchers then created a simulated inflammatory periodontal disease environment in the petri dishes. Next, they added two specific types of synthetic molecules called Maresin-1 (Mar1) and Resolvin-E1 (Rve1), both specialised pro-resolving lipid mediators from omega-3 fatty acids. The scientists found that Mar1 and RvE1 stimulated the stem cells to regenerate even under the inflammatory conditions.

This finding is important because it allows scientists to identify the specific protein pathways involved in inflammation. Those same protein pathways are consistent across many systemic diseases, including periodontal disease, diabetes, heart disease, dementia, and obesity.

Dr Kantarci said: “The mechanism we identified could one day be used for building complex organs”.